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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAPKAPK5
All Species:
17.27
Human Site:
S440
Identified Species:
31.67
UniProt:
Q8IW41
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IW41
NP_003659.2
473
54220
S440
R
D
T
L
Q
S
F
S
W
N
G
R
G
F
T
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001102910
666
74053
S633
R
D
T
L
Q
S
F
S
W
N
G
R
G
F
T
Dog
Lupus familis
XP_534678
804
89494
S771
R
D
T
L
Q
S
F
S
W
N
G
R
G
F
T
Cat
Felis silvestris
Mouse
Mus musculus
O54992
473
54134
S440
R
D
A
L
Q
S
F
S
W
N
G
R
G
F
T
Rat
Rattus norvegicus
Q66H84
384
43204
I353
V
D
Y
D
Q
V
K
I
K
D
L
K
T
S
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521063
278
31941
F251
F
S
W
N
G
R
G
F
T
D
K
V
D
R
L
Chicken
Gallus gallus
Q5F3L1
789
89022
E675
M
S
S
L
R
Y
N
E
W
L
Q
D
G
S
Q
Frog
Xenopus laevis
NP_001085020
377
43533
I350
M
R
V
D
Y
E
Q
I
K
I
K
K
I
E
D
Zebra Danio
Brachydanio rerio
NP_001002336
471
53898
C438
R
D
G
L
H
G
L
C
W
D
G
R
S
F
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P49071
359
41383
D332
Q
M
Q
I
K
A
L
D
K
S
N
N
P
L
L
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
NP_500006
366
41523
K339
K
L
L
A
K
R
R
K
G
G
A
S
P
K
D
Sea Urchin
Strong. purpuratus
XP_001194739
473
54175
S441
D
K
A
L
N
N
L
S
W
N
G
E
Q
F
C
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9ZV15
583
64702
S517
D
H
L
F
T
A
F
S
Y
F
D
Q
D
G
S
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
70.7
58
N.A.
97.2
34.4
N.A.
57.2
21.1
34
87
N.A.
32.3
N.A.
34.6
56
Protein Similarity:
100
N.A.
70.7
58.3
N.A.
98.7
52.8
N.A.
58.1
35.3
52
94.2
N.A.
49.2
N.A.
52.4
72.3
P-Site Identity:
100
N.A.
100
100
N.A.
93.3
13.3
N.A.
0
20
0
46.6
N.A.
0
N.A.
0
40
P-Site Similarity:
100
N.A.
100
100
N.A.
93.3
26.6
N.A.
6.6
33.3
6.6
60
N.A.
33.3
N.A.
13.3
46.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
21.1
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
37.3
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
40
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
16
8
0
16
0
0
0
0
8
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
8
% C
% Asp:
16
47
0
16
0
0
0
8
0
24
8
8
16
0
16
% D
% Glu:
0
0
0
0
0
8
0
8
0
0
0
8
0
8
0
% E
% Phe:
8
0
0
8
0
0
39
8
0
8
0
0
0
47
0
% F
% Gly:
0
0
8
0
8
8
8
0
8
8
47
0
39
8
0
% G
% His:
0
8
0
0
8
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
8
0
0
0
16
0
8
0
0
8
0
0
% I
% Lys:
8
8
0
0
16
0
8
8
24
0
16
16
0
8
0
% K
% Leu:
0
8
16
54
0
0
24
0
0
8
8
0
0
8
16
% L
% Met:
16
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
8
8
8
8
0
0
39
8
8
0
0
8
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
16
0
0
% P
% Gln:
8
0
8
0
39
0
8
0
0
0
8
8
8
0
8
% Q
% Arg:
39
8
0
0
8
16
8
0
0
0
0
39
0
8
0
% R
% Ser:
0
16
8
0
0
31
0
47
0
8
0
8
8
16
16
% S
% Thr:
0
0
24
0
8
0
0
0
8
0
0
0
8
0
31
% T
% Val:
8
0
8
0
0
8
0
0
0
0
0
8
0
0
0
% V
% Trp:
0
0
8
0
0
0
0
0
54
0
0
0
0
0
0
% W
% Tyr:
0
0
8
0
8
8
0
0
8
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _